Abstract
Interleukin-1β is a cytokine critically involved in immune and inflammatory responses. To extend its use as a component of avian vaccines, a circularly permuted chicken interleukin-1β was synthesized that maintains its activity after pre-incubation at high temperatures, unlike wild-type chicken interleukin-1β, which is irreversibly inactivated at high temperatures.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Chickens / immunology
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Chickens / metabolism*
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Circular Dichroism
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Fluorescence
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Hot Temperature*
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Interleukin-1beta / chemistry*
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Interleukin-1beta / genetics
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Interleukin-1beta / metabolism
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Mutation / genetics
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Protein Stability*
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Receptors, Interleukin-1 / metabolism
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Surface Plasmon Resonance
Substances
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Interleukin-1beta
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Receptors, Interleukin-1