Ruthenium(II)-catalyzed C(sp3)-H α-alkylation of pyrrolidines

Org Lett. 2014 Apr 4;16(7):1876-9. doi: 10.1021/ol500300w. Epub 2014 Mar 18.

Abstract

A catalytic system comprising [RuCl2(PPh3)3], AgOTf, and BINAP enabled atom- and step-economical additions of C(sp(3))-H bonds onto unactivated alkenes 2 under comparably mild reaction conditions. The pyridyl directing group was easily removed to furnish the corresponding (NH)-free amines with ample scope.