Antifungal lock therapy with combined 70% ethanol and micafungin in a critically ill infant

Pediatr Infect Dis J. 2014 Apr;33(4):419-20. doi: 10.1097/INF.0000000000000116.

Abstract

So-called lock therapy, consisting of high concentrations of antimicrobials instilled into the lumen of the catheter, has been suggested avoid central venous catheter removal during fungal infection. We report a baby who developed catheter-related candidemia. Systemic antifungal treatment did not resolve the candidemia. Lock therapy with 0.3 mL of ethanol 70% and micafungin sodium 5 mg/L was added to the therapy, and blood cultures became sterile.

Publication types

  • Case Reports

MeSH terms

  • Antifungal Agents / therapeutic use*
  • Candida albicans / isolation & purification
  • Candidemia / drug therapy*
  • Catheter-Related Infections / drug therapy*
  • Catheter-Related Infections / microbiology
  • Central Venous Catheters / adverse effects
  • Central Venous Catheters / microbiology*
  • Critical Illness
  • Echinocandins / therapeutic use*
  • Ethanol / therapeutic use*
  • Failure to Thrive
  • Humans
  • Infant
  • Lipopeptides / therapeutic use*
  • Male
  • Micafungin
  • Parenteral Nutrition

Substances

  • Antifungal Agents
  • Echinocandins
  • Lipopeptides
  • Ethanol
  • Micafungin