n-Bu₄NI-catalyzed selective dual amination of sp³ C-H bonds: oxidative domino synthesis of imidazo[1,5-c]quinazolines on a gram-scale

Dan Zhao; Teng Wang; Qi Shen; Jian-Xin Li

doi:10.1039/c4cc01444h

n-Bu₄NI-catalyzed selective dual amination of sp³ C-H bonds: oxidative domino synthesis of imidazo[1,5-c]quinazolines on a gram-scale

Chem Commun (Camb). 2014 Apr 28;50(33):4302-4. doi: 10.1039/c4cc01444h.

Authors

Dan Zhao¹, Teng Wang, Qi Shen, Jian-Xin Li

Affiliation

¹ State Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, P. R. China. [email protected].

PMID: 24637953
DOI: 10.1039/c4cc01444h

Abstract

An n-Bu4NI catalyzed domino reaction that involves selective dual amination of sp(3) C-H bonds has been developed. The protocol affords a facile and efficient approach to the synthesis of imidazo[1,5-c]quinazolines under mild conditions.