KIBRA: In the brain and beyond

Cell Signal. 2014 Jul;26(7):1392-9. doi: 10.1016/j.cellsig.2014.02.023. Epub 2014 Mar 15.

Abstract

In mammals, the KIBRA locus has been associated with memory performance and cognition by genome-wide single nucleotide polymorphism screening. Genetic studies in Drosophila and human cells have identified KIBRA as a novel regulator of the Hippo signaling pathway, which plays a critical role in human tumorigenesis. Recent studies also indicated that KIBRA is involved in other physiological processes including cell polarity, membrane/vesicular trafficking, mitosis and cell migration. At the biochemical level, KIBRA protein is highly phosphorylated by various kinases in epithelial cells. Here, we discuss the updates concerning the function and regulation of KIBRA in the brain and beyond.

Keywords: Cell migration; Cell polarity; Hippo pathway; KIBRA; Memory performance; Phosphorylation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Brain / metabolism*
  • Carcinogenesis / genetics*
  • Cell Movement / genetics
  • Cell Polarity / genetics
  • Cognition / physiology
  • Drosophila
  • Hippo Signaling Pathway
  • Humans
  • Intracellular Signaling Peptides and Proteins / genetics*
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Kidney / metabolism*
  • Memory / physiology
  • Mice
  • Mitosis / genetics
  • Molecular Sequence Data
  • Phosphoproteins / genetics*
  • Phosphoproteins / metabolism*
  • Protein Serine-Threonine Kinases / genetics
  • Protein Transport / genetics

Substances

  • Intracellular Signaling Peptides and Proteins
  • Phosphoproteins
  • WWC1 protein, human
  • Protein Serine-Threonine Kinases