Abstract
We have observed that iloprost, a prostacyclin analog, causes the translocation of a 23-kDa protein from the membrane to the cytosol of human platelets. This 23-kDa protein is recognized by a Gs alpha (alpha subunit of stimulatory guanine nucleotide binding regulatory protein) antiserum but is not ADP-ribosylated by cholera toxin. The translocation of the Gs alpha-related protein might be an important part of the complex chain of events resulting in agonist-induced desensitization.
MeSH terms
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Blood Platelets / metabolism*
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Cardiovascular Agents / pharmacology
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Cell Membrane / drug effects
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Cell Membrane / metabolism
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Cytosol / metabolism
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Epoprostenol / pharmacology*
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GTP-Binding Proteins / blood*
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GTP-Binding Proteins / immunology
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GTP-Binding Proteins / isolation & purification
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Humans
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Iloprost
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Immune Sera
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Macromolecular Substances
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Molecular Weight
Substances
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Cardiovascular Agents
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Immune Sera
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Macromolecular Substances
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Epoprostenol
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GTP-Binding Proteins
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Iloprost