The nucleophilicity of a dialkylcarbene: unusual activation parameters for additions of adamantanylidene to simple alkenes

J Am Chem Soc. 2014 Apr 2;136(13):4885-8. doi: 10.1021/ja501410x. Epub 2014 Mar 20.

Abstract

Computational and experimental results demonstrate that adamantanylidene (1) behaves as a highly reactive nucleophile toward common alkenes. It is the only known saturated nucleophilic carbene that lacks direct or vinylogous heteroatomic substitution. The activation energy and enthalpy for addition of 1 to methyl acrylate are the most negative values yet encountered in any carbene-alkene addition.