Nodular lymphocyte predominant hodgkin lymphoma: biology, diagnosis and treatment

Anupama Goel; Wen Fan; Amit A Patel; Madhuri Devabhaktuni; Michael L Grossbard

doi:10.1016/j.clml.2014.01.006

Nodular lymphocyte predominant hodgkin lymphoma: biology, diagnosis and treatment

Clin Lymphoma Myeloma Leuk. 2014 Aug;14(4):261-70. doi: 10.1016/j.clml.2014.01.006. Epub 2014 Feb 3.

Authors

Anupama Goel¹, Wen Fan², Amit A Patel³, Madhuri Devabhaktuni³, Michael L Grossbard²

Affiliations

¹ Department of Hematology and Oncology, St Luke's Roosevelt Hospital Center, New York, NY; Mt Sinai Health System. Electronic address: [email protected].
² Department of Hematology and Oncology, St Luke's Roosevelt Hospital Center, New York, NY; Mt Sinai Health System.
³ Department of Hematology and Oncology, St Luke's Roosevelt Hospital Center, New York, NY.

PMID: 24650975
DOI: 10.1016/j.clml.2014.01.006

Abstract

Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is an uncommon variant of classical Hodgkin lymphoma. It is characterized histologically by presence of lymphohistiocytic cells which have B-cell phenotype, are positive for CD19, CD20, CD45, CD79a, BOB.1, Oct.2, and negative for CD15 and CD30. Patients often present with early stage of disease and do not have classical B symptoms. The clinical behavior appears to mimic that of an indolent non-Hodgkin lymphoma more than that of classical Hodgkin disease. The purpose of the present report is to define the biology of NLPHL, review its clinical presentation, and summarize the available clinical data regarding treatment.

Keywords: Hodgkin lymphoma; LP cell; NLPHL; Popcorn cell; Reed Sternberg cells.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

B-Lymphocytes / metabolism
B-Lymphocytes / pathology
Disease Progression
Hodgkin Disease / diagnosis*
Hodgkin Disease / epidemiology
Hodgkin Disease / etiology
Hodgkin Disease / therapy*
Humans
Neoplasm Staging
Neoplasms, Second Primary / etiology
Phenotype
Recurrence