The AML salad bowl

Jesús Duque-Afonso; Michael L Cleary

doi:10.1016/j.ccr.2014.03.002

The AML salad bowl

Cancer Cell. 2014 Mar 17;25(3):265-7. doi: 10.1016/j.ccr.2014.03.002.

Authors

Jesús Duque-Afonso¹, Michael L Cleary²

Affiliations

¹ Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
² Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: [email protected].

Abstract

Tumors arise from single cells but become genetically heterogeneous through continuous acquisition of somatic mutations as they progress. In this issue of Cancer Cell, Klco and colleagues used whole genome sequence analysis to demonstrate the correlation of genetic clonal architecture with functional heterogeneity in acute myeloid leukemia.

Publication types

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MeSH terms

Animals
Clonal Evolution / genetics*
Genetic Variation / genetics*
Humans
Leukemia, Myeloid, Acute / genetics*

Abstract

Publication types

MeSH terms

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