Capture and release of cancer cells based on sacrificeable transparent MnO2 nanospheres thin film

Adv Healthc Mater. 2014 Sep;3(9):1420-5. doi: 10.1002/adhm.201300670. Epub 2014 Mar 20.

Abstract

A CTCs detection assay using transparent MnO2 nanospheres thin films to capture and release of CTCs is reported. The enhanced local topography interaction between extracellular matrix scaffolds and the antibody-coated substrate leads to improved capture efficiency. CTCs captured from artificial blood sample can be cultured and released, represent a new functional material capable of CTCs isolation and culture for subsequent studies.

Keywords: MnO2 nanospheres; cell release; circulating tumor cells; transparent.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies / chemistry
  • Antibodies / metabolism
  • Antigens, Neoplasm / metabolism
  • Cell Adhesion Molecules / metabolism
  • Cell Line, Tumor
  • Cell Separation / instrumentation*
  • Cell Survival
  • Epithelial Cell Adhesion Molecule
  • Humans
  • Manganese Compounds / chemistry*
  • Nanospheres / chemistry*
  • Nanospheres / ultrastructure
  • Nanostructures
  • Neoplastic Cells, Circulating / chemistry
  • Neoplastic Cells, Circulating / metabolism*
  • Oxalic Acid
  • Oxides / chemistry*

Substances

  • Antibodies
  • Antigens, Neoplasm
  • Cell Adhesion Molecules
  • Epithelial Cell Adhesion Molecule
  • Manganese Compounds
  • Oxides
  • Oxalic Acid
  • manganese dioxide