The localisation of fibrin, fibronectin and class II major histocompatibility complex antigen in the spinal cord in chronic relapsing experimental allergic encephalomyelitis

J Neuroimmunol. 1989 Mar;22(1):11-7. doi: 10.1016/0165-5728(89)90003-9.

Abstract

Light and electron immunocytochemistry using antibodies recognising a class II major histocompatibility complex antigen, fibrin, fibronectin, albumin and factor VIII related antigen has been used to stain sections of spinal cord from normal guinea pigs and those with chronic relapsing experimental allergic encephalomyelitis (CREAE). It was found that class II MHC antigens, fibrin and fibronectin were present in normal blood vessels and at high levels in lesions from animals at all stages of the disease. The possible immunological roles of these antigens suggest their participation in the initiation and maintenance of disease state.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal
  • Blood Vessels / analysis
  • Chronic Disease
  • Encephalomyelitis, Autoimmune, Experimental / immunology
  • Encephalomyelitis, Autoimmune, Experimental / metabolism*
  • Encephalomyelitis, Autoimmune, Experimental / pathology
  • Fibrin / analysis*
  • Fibronectins / analysis*
  • Guinea Pigs
  • Histocompatibility Antigens Class II / analysis*
  • Immunologic Techniques
  • Microscopy, Electron
  • Recurrence
  • Spinal Cord / analysis*
  • Spinal Cord / blood supply
  • Spinal Cord / pathology
  • Staining and Labeling

Substances

  • Antibodies, Monoclonal
  • Fibronectins
  • Histocompatibility Antigens Class II
  • Fibrin