A simple one-step method for preparation of fluorescent carbon nanospheres and the potential application in cell organelles imaging

Shaobo Ruan; Biyue Zhu; Huajin Zhang; Jiantao Chen; Shun Shen; Jun Qian; Qin He; Huile Gao

doi:10.1016/j.jcis.2014.02.006

A simple one-step method for preparation of fluorescent carbon nanospheres and the potential application in cell organelles imaging

J Colloid Interface Sci. 2014 May 15:422:25-9. doi: 10.1016/j.jcis.2014.02.006. Epub 2014 Feb 13.

Authors

Shaobo Ruan¹, Biyue Zhu¹, Huajin Zhang¹, Jiantao Chen¹, Shun Shen², Jun Qian², Qin He¹, Huile Gao³

Affiliations

¹ Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041, China.
² Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education, Department of Pharmaceutics Sciences, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China.
³ Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041, China. Electronic address: [email protected].

PMID: 24655824
DOI: 10.1016/j.jcis.2014.02.006

Abstract

Highly fluorescent carbon nanospheres with a quantum yield of 17.6% have been prepared by a one-step method with hydrothermal treatment of spider silk. Due to the high photostability, low toxicity and well blood compatibility, these carbon nanospheres could be used as an excellent probes for cancer cell imaging.

Keywords: Cancer cell imaging; Carbon nanospheres; Fluorescence.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carbon / chemistry*
Cell Line, Tumor
Humans
Microscopy, Electron, Transmission
Nanostructures*
Organelles / ultrastructure*
Spectrophotometry, Ultraviolet

Substances

Carbon