Heterocyclic aminoparthenolide derivatives modulate G(2)-M cell cycle progression during Xenopus oocyte maturation

Bioorg Med Chem Lett. 2014 Apr 15;24(8):1963-7. doi: 10.1016/j.bmcl.2014.02.067. Epub 2014 Mar 4.

Abstract

Aminoparthenolide derivatives have been prepared by reaction of parthenolide with various heterocyclic amines to afford corresponding Michael addition products. These novel compounds were evaluated for their modulatory effects on Xenopus oocyte maturation. Two compounds, 6e and 6f, were identified that promote G2-M cell cycle progression.

Keywords: Heterocyclic amines; Michael addition; Oocyte maturation; Parthenolide; Progesterone.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dose-Response Relationship, Drug
  • G2 Phase / drug effects
  • Heterocyclic Compounds / chemistry
  • Heterocyclic Compounds / pharmacology
  • Mitosis / drug effects*
  • Molecular Structure
  • Oocytes / drug effects*
  • Oocytes / growth & development*
  • Oocytes / metabolism
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / pharmacology
  • Xenopus

Substances

  • Heterocyclic Compounds
  • Sesquiterpenes
  • parthenolide