Diagnostic accuracy and practice effects in the National Alzheimer's Coordinating Center Uniform Data Set neuropsychological battery

Alzheimers Dement. 2014 Nov;10(6):675-83. doi: 10.1016/j.jalz.2013.11.007. Epub 2014 Mar 20.

Abstract

Introduction: The Uniform Data Set (UDS) neuropsychological battery is frequently used in clinical studies. However, practice effects, effectiveness as a measure of global cognitive functioning, and detection of mild cognitive impairment have not been examined.

Methods: A normative total score for the UDS has been developed. Linear discriminant analysis determined classification accuracy in identifying cognitively normal and impaired groups. Practice effects were examined in cognitively normal and cognitively impaired groups.

Results: The total score differentiates between cognitively normal participants and those with dementia, but does not accurately identify individuals with mild cognitive impairment (MCI). Mean total scores for test-exposed participants were significantly higher than test-naive participants in both the normal and MCI groups and were higher, but not significantly so, in the dementia group.

Conclusion: The total score's classification accuracy discriminates between cognitively normal versus participants who have dementia. The total score appears subject to practice effects.

Keywords: Aging; Cognitive testing; Diagnostic accuracy; Longitudinal data; Practice effects.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / complications
  • Alzheimer Disease / diagnosis*
  • Cognition Disorders / classification
  • Cognition Disorders / etiology
  • Data Collection / methods
  • Female
  • Humans
  • Male
  • Memory Disorders / etiology
  • Middle Aged
  • Neuropsychological Tests* / standards
  • Neuropsychological Tests* / statistics & numerical data
  • Reference Values
  • Regression Analysis
  • United States