Multifunctional PEGylated multiwalled carbon nanotubes for enhanced blood pool and tumor MR imaging

Shihui Wen; Qinghua Zhao; Xiao An; Jingyi Zhu; Wenxiu Hou; Kai Li; Yunpeng Huang; Mingwu Shen; Wei Zhu; Xiangyang Shi

doi:10.1002/adhm.201300631

Multifunctional PEGylated multiwalled carbon nanotubes for enhanced blood pool and tumor MR imaging

Adv Healthc Mater. 2014 Oct;3(10):1568-77, 1525. doi: 10.1002/adhm.201300631. Epub 2014 Mar 24.

Authors

Shihui Wen¹, Qinghua Zhao, Xiao An, Jingyi Zhu, Wenxiu Hou, Kai Li, Yunpeng Huang, Mingwu Shen, Wei Zhu, Xiangyang Shi

Affiliation

¹ State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai, 201620, China; College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, China.

PMID: 24665035
DOI: 10.1002/adhm.201300631

Abstract

Long-circulating multifunctional Gd(III)-loaded multiwalled carbon nanotubes (MWCNTs) modified with polyethylene glycol are designed and synthesized. The formed MWCNTs are water-dispersible, stable, and have good cytocompatibility and antifouling property. With the low r 2 /r 1 relaxivity ratio and relatively long blood circulation time, the multifunctional MWCNTs are able to be used as a platform for enhanced blood pool and tumor MR imaging.

Keywords: PEGylation; blood pool MR imaging; multiwalled carbon nanotubes; polyethyleneimine; tumor MR imaging.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Gated Blood-Pool Imaging / methods*
Magnetic Resonance Imaging / methods*
Mice
Molecular Imaging / methods*
Nanotubes, Carbon / chemistry*
Neoplasms, Experimental / diagnosis*
Neoplasms, Experimental / diagnostic imaging
Neoplasms, Experimental / pathology
Polyethylene Glycols*

Substances

Nanotubes, Carbon
Polyethylene Glycols