Abstract
Two new lignans, 9-salicyl-(+)-isolariciresinol (1) and gaultheroside G (2), together with seven known compounds, were isolated from the ethanolic extract of the whole plant of Gaultheria yunnanensis. Their structures were determined by extensive NMR and MS analyses. Gaultheroside G (2) was found to have an unusual ether linkage between the 2 and 9' positions of aryl-tetralin lignan skeleton. All nine compounds were assayed for inhibitory effects against nitric oxide and pro-inflammatory cytokines TNF-α and IL-6 release in LPS-induced RAW 246.7 macrophages, while no significant activities were observed for the evaluated compounds.
Keywords:
Ericaceae; Gaultheria yunnanensis; anti-inflammatory activity; lignans.
MeSH terms
-
Animals
-
Anti-Inflammatory Agents / chemistry
-
Anti-Inflammatory Agents / isolation & purification*
-
Anti-Inflammatory Agents / pharmacology
-
Gaultheria / chemistry*
-
Interleukin-6 / antagonists & inhibitors
-
Interleukin-6 / pharmacology
-
Lignans / chemistry
-
Lignans / isolation & purification*
-
Lignans / pharmacology
-
Lipopolysaccharides / pharmacology
-
Macrophages / drug effects
-
Mice
-
Molecular Structure
-
Nitric Oxide / biosynthesis
-
Protein Precursors
-
Tumor Necrosis Factor-alpha / drug effects
Substances
-
9-salicyl-isolariciresinol
-
Anti-Inflammatory Agents
-
Interleukin-6
-
Lignans
-
Lipopolysaccharides
-
Protein Precursors
-
Tumor Necrosis Factor-alpha
-
gaultheroside G
-
Nitric Oxide
-
tumor necrosis factor precursor