Overview of vertebrate animal models of fungal infection

Tobias M Hohl

doi:10.1016/j.jim.2014.03.022

Overview of vertebrate animal models of fungal infection

J Immunol Methods. 2014 Aug:410:100-12. doi: 10.1016/j.jim.2014.03.022. Epub 2014 Apr 4.

Author

Tobias M Hohl¹

Affiliation

¹ Department of Medicine, Infectious Diseases Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 9, New York, NY 10075, United States. Electronic address: [email protected].

Abstract

Fungi represent emerging infectious threats to human populations worldwide. Mice and other laboratory animals have proved invaluable in modeling clinical syndromes associated with superficial and life-threatening invasive mycoses. This review outlines salient features of common vertebrate animal model systems to study fungal pathogenesis, host antifungal immune responses, and antifungal compounds.

Keywords: Animal model; Fungus; Immune response; Mouse; Pathogenesis; Yeast.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Disease Models, Animal*
Humans
Mycoses* / immunology
Mycoses* / metabolism
Mycoses* / pathology

Abstract

Publication types

MeSH terms

Grants and funding