Nasal polyposis and immunoglobulin-G subclass deficiency

Eur Ann Otorhinolaryngol Head Neck Dis. 2014 Jun;131(3):171-5. doi: 10.1016/j.anorl.2013.11.002. Epub 2014 Apr 5.

Abstract

Objective: Study of the association between immunoglobulin-G (IgG) subclass deficiency and nasal polyposis.

Material and methods: Longitudinal study (5 years) in a prospective cohort of 161 nasal polyposis patients. Analysis of the association between humoral immunodeficiency, rhinologic symptoms, endoscopy score and prescribed doses of local and systemic corticosteroids.

Results: The prevalence of IgG subclass deficiency was 13.7% (22/161). One patient was diagnosed with common variable immunodeficiency (CVID). No significant differences were observed between the groups with and without pre-treatment deficiency for symptom severity, endoscopic score or local or systemic corticosteroid regimens at baseline or during the 5 years, following initiation of medical and surgical treatment. Only the Lund-Mackay CT score was significantly higher in the pre-treatment deficiency group.

Conclusion: There was no correlation between the presence of humoral deficiency and either symptom evolution after medical and surgical treatment or the dose of corticosteroids needed to control disease. Thus, a link between IgG subclass deficiency and nasal polyposis seems unlikely.

Keywords: IgG; IgG subclasses; Immunodeficiency; Nasal polyposis; Sinus.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Beclomethasone / therapeutic use
  • Common Variable Immunodeficiency / diagnosis
  • Female
  • Glucocorticoids / therapeutic use
  • Humans
  • IgG Deficiency / diagnosis*
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Nasal Obstruction / etiology
  • Nasal Obstruction / therapy
  • Nasal Polyps / complications*
  • Nasal Polyps / therapy
  • Olfaction Disorders / etiology
  • Olfaction Disorders / therapy
  • Prospective Studies
  • Young Adult

Substances

  • Glucocorticoids
  • Beclomethasone