Which is the optimal algorithm for the prevention of neonatal early-onset group B streptococcus sepsis?

Chryssoula Tzialla; Alessandro Borghesi; Stefania Longo; Mauro Stronati

doi:10.1016/S0378-3782(14)70012-X

Which is the optimal algorithm for the prevention of neonatal early-onset group B streptococcus sepsis?

Early Hum Dev. 2014 Mar:90 Suppl 1:S35-8. doi: 10.1016/S0378-3782(14)70012-X.

Authors

Chryssoula Tzialla¹, Alessandro Borghesi², Stefania Longo², Mauro Stronati²

Affiliations

¹ Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. Electronic address: [email protected].
² Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

PMID: 24709454
DOI: 10.1016/S0378-3782(14)70012-X

Abstract

The incidence of neonatal early-onset group B streptococcus (GBS EOS) sepsis has declined during the last decade since the implementation of intrapartum antibiotic prophylaxis endorsed by Centers for Disease Control and Prevention (CDC) guidelines. All the CDC guidelines versions provide recommendations for neonatal management. The neonatal algorithm of CDC has not been universally accepted and hence different algorithms have been suggested. Since all approaches to disease prevention are still imperfect, an optimal algorithm for GBS EOS prevention is still lacking; the development of improved diagnostic methods of distinguishing at-risk infants may contribute to improve the clinician's approach.

Keywords: Group B streptococcal disease; Neonate; Prevention.

Publication types

Review

MeSH terms

Antibiotic Prophylaxis / methods
Antibiotic Prophylaxis / standards*
Centers for Disease Control and Prevention, U.S.
Guidelines as Topic*
Humans
Infant, Newborn
Streptococcal Infections / congenital
Streptococcal Infections / prevention & control*
Streptococcus agalactiae / pathogenicity
United States