Abstract
Combination of thyroid blocking agents do not seem to be embryo- and fetotoxic when applied in reduced doses. These agents decrease significantly the radioiodine uptake by fetuses and sucklings. By extrapolation of these results to humans, based on the mass-unit efficient doses [13, 16, 23, 24], their combination can be recommended for the prophylaxis of radioiodine intoxication of fetuses and infants.
MeSH terms
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Age Factors
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Animals
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Animals, Newborn / metabolism*
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Animals, Suckling / metabolism
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Antithyroid Agents / pharmacology*
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Female
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Fetus / metabolism*
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Iodine Radioisotopes / administration & dosage
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Iodine Radioisotopes / metabolism*
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Perchlorates / pharmacology
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Potassium / pharmacology
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Potassium Compounds*
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Potassium Iodide / pharmacology
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Pregnancy
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Rats
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Rats, Inbred Strains
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Thyroid Gland / metabolism
Substances
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Antithyroid Agents
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Iodine Radioisotopes
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Perchlorates
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Potassium Compounds
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Potassium Iodide
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potassium perchlorate
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Potassium