Three new cucurbitane triterpenoids from Hemsleya penxianensis and their cytotoxic activities

Bioorg Med Chem Lett. 2014 May 1;24(9):2159-62. doi: 10.1016/j.bmcl.2014.03.027. Epub 2014 Mar 20.

Abstract

Two new cucurbitane glycosides, hemslepenside A (1) and 16,25-O-diacetyl-cucurbitacin F-2-O-β-d-glucopyranoside (3), one new cucurbitacin, 16-O-acetyl-cucurbitacin F (2), along with three known cucurbitane compounds, were isolated from the roots of Hemsleya penxianensis. The structures of 1-6 were established on the basis of extensive spectroscopic and chemical methods. The isolated compounds were evaluated for their cytotoxic activities against different three human cancer cell lines, with IC50 values in the low microgram range.

Keywords: Cucurbitane triterpenoids; Cytotoxic activities; Hemsleya penxianensis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Line, Tumor
  • Cucurbitaceae / chemistry*
  • Glycosides / chemistry*
  • Glycosides / isolation & purification
  • Glycosides / pharmacology*
  • Humans
  • Neoplasms / drug therapy
  • Plant Roots / chemistry
  • Triterpenes / chemistry*
  • Triterpenes / isolation & purification
  • Triterpenes / pharmacology*

Substances

  • Antineoplastic Agents, Phytogenic
  • Glycosides
  • Triterpenes
  • cucurbitane