[Immune-mediated inflammatory diseases in patients with inflammatory bowel disease. Baseline data from the Aquiles study]

Gastroenterol Hepatol. 2014 Nov;37(9):495-502. doi: 10.1016/j.gastrohep.2014.02.010. Epub 2014 Apr 8.
[Article in Spanish]

Abstract

Objective: To determine the prevalence of immune-mediated inflammatory diseases (IMID) in a cohort of patients with inflammatory bowel disease (IBD) enrolled in hospital gastroenterology outpatients units for the AQUILES study, a prospective 2-year follow-up study.

Material and methods: We included patients ≥18 years old with a prior or new diagnosis of IBD (Crohn disease [CD], ulcerative colitis [UC] or indeterminate colitis). Diagnoses were collected in a cross-sectional manner from the clinical records at enrollment of a new patient in the study.

Results: We included 526 patients (mean age 40.2 years; 47.3% men, 52.7% women), 300 with CD (57.0%), 218 with UC (41.4%) and 8 with indeterminate colitis. Other types of IMID were present in 71 patients (prevalence: 13.5%, 95% CI: 10.8-16.7): 47 were spondyloarthropathies (prevalence: 8.9%); 18 psoriasis (3.4%); 5 pyoderma gangrenosum (1.0%), and 11 uveitis (2.1%). The prevalence of IMID was higher in patients with CD than in those with UC (17.0% [95% CI: 13.2-21.7] vs 9.2% [95% CI: 6.0-13.8], p=0.011). In the multivariate analysis, the variables associated with the presence of IMID were diagnosis of CD (OR=1.8 [95% CI: 1.1-3.2]) and duration of IBD ≥4 years (OR=2.1 [95% CI: 1.1-4.1] in those with disease duration 4-8 years, and OR=2.1 [95% CI: 1.2-3.9] in those with ≥8 years vs. <4 years).

Conclusions: In the cohort of patients with IBD in the AQUILES study, 13.5% had another IMID, with a higher prevalence in patients with CD and>4 years since disease onset.

Keywords: Colitis ulcerosa; Crohn disease; Enfermedad de Crohn; Enfermedad inflamatoria intestinal; Enfermedad inflamatoria mediada inmunológicamente; Extraintestinal manifestation; Immune-mediate inflammatory disease; Inflammatory bowel disease; Manifestación extraintestinal; Ulcerative colitis.

Publication types

  • Multicenter Study

MeSH terms

  • Adult
  • Autoimmune Diseases / epidemiology
  • Autoimmune Diseases / immunology
  • Colitis / epidemiology
  • Colitis, Ulcerative / epidemiology*
  • Colitis, Ulcerative / immunology
  • Comorbidity
  • Crohn Disease / epidemiology*
  • Crohn Disease / immunology
  • Cross-Sectional Studies
  • Female
  • Follow-Up Studies
  • Genetic Predisposition to Disease
  • Humans
  • Inflammatory Bowel Diseases / epidemiology*
  • Inflammatory Bowel Diseases / immunology
  • Male
  • Middle Aged
  • Psoriasis / epidemiology
  • Pyoderma Gangrenosum / epidemiology
  • Spondylarthritis / epidemiology
  • Uveitis / epidemiology