Palliative effect of capecitabine and cetuximab for refractory metastatic squamous cell carcinoma of the perineum in epidermodysplasia verruciformis

Skinmed. 2014 Jan-Feb;12(1):54-6.

Abstract

A teenage girl presented with multiple warty skin lesions and had a diagnosis of epidermodysplasia verruciformis made several years later. Later in life she presented with an extensive SCC in situ in her gluteal crease that was surgically resected with wide margins. Despite this treatment, the lesion recurred with extension onto her lower back. Biopsies at the time confirmed SCC in situ of the perianal tissue and invasive SCC above her gluteal cleft.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antibodies, Monoclonal, Humanized / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Biopsy
  • Capecitabine
  • Carcinoma in Situ / drug therapy
  • Carcinoma in Situ / pathology
  • Carcinoma in Situ / virology
  • Carcinoma, Squamous Cell / drug therapy*
  • Carcinoma, Squamous Cell / pathology
  • Carcinoma, Squamous Cell / virology
  • Cetuximab
  • Deoxycytidine / administration & dosage
  • Deoxycytidine / analogs & derivatives
  • Epidermodysplasia Verruciformis / complications*
  • Epidermodysplasia Verruciformis / pathology
  • Female
  • Fluorouracil / administration & dosage
  • Fluorouracil / analogs & derivatives
  • Humans
  • Neoplasm Invasiveness
  • Palliative Care / methods
  • Perineum / pathology
  • Skin Neoplasms / drug therapy*
  • Skin Neoplasms / pathology
  • Skin Neoplasms / virology

Substances

  • Antibodies, Monoclonal, Humanized
  • Deoxycytidine
  • Capecitabine
  • Cetuximab
  • Fluorouracil