Trial design for breakthrough pain: is it ethical to have a placebo in a trial?

Clin Ther. 2014 May;36(5):814-5. doi: 10.1016/j.clinthera.2014.03.005. Epub 2014 Apr 13.

Authors

Mellar P Davis¹, Eduardo Bruera²

Affiliations

¹ Cleveland Clinic Lerner School of Medicine, Case Western Reserve University, Cleveland, Ohio; Palliative Medicine and Supportive Oncology Services, Division of Solid Tumor, Taussig Cancer Institute, The Cleveland Clinic, Cleveland, Ohio.
² Department of Palliative Care & Rehabilitation Medicine, F.T. McGraw Chair in the Treatment of Cancer, 1515 Holcombe Boulevard, Unit 1414, Houston, TX 77030.

PMID: 24726089
DOI: 10.1016/j.clinthera.2014.03.005

No abstract available

Publication types

Letter
Comment

MeSH terms

Analgesics, Opioid / administration & dosage*
Analgesics, Opioid / therapeutic use*
Breakthrough Pain / drug therapy*
Female
Fentanyl / administration & dosage*
Fentanyl / therapeutic use*
Humans
Male

Substances

Analgesics, Opioid
Fentanyl