Novel helical TiO2 nanotube arrays modified by Cu2O for enzyme-free glucose oxidation

Biosens Bioelectron. 2014 Sep 15:59:243-50. doi: 10.1016/j.bios.2014.03.032. Epub 2014 Mar 29.

Abstract

A helical TiO2 nanotube (TNT) array modified with cuprous oxide (Cu2O) electrode was fabricated and used for nonenzymatic glucose detection. The structure and morphology of Cu2O/TNT were characterized by X-ray diffraction and transmission electron microscopy. The electrocatalytic performance of Cu2O/TNT electrode for glucose oxidation was investigated by cyclic voltammetry and chronoamperometry. At an applied potential of +0.65 V versus SCE, a linear range was obtained within the concentration range of 3.0-9.0 mM with a detection limit of 62 μM (signal/noise=3). The response time was approximately 3 s after adding 0.10 mM glucose. Formate and gluconic acid were identified as the main products of the glucose oxidation using (1)H NMR spectrometry. A possible mechanism for continuous glucose oxidation was also proposed.

Keywords: Cu(2)O/TiO(2); Electrochemical property; Nanotube array; Sensor.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biosensing Techniques / instrumentation*
  • Blood Glucose / analysis*
  • Copper / chemistry*
  • Electrochemical Techniques / instrumentation
  • Electrodes
  • Humans
  • Limit of Detection
  • Nanotubes / chemistry*
  • Nanotubes / ultrastructure
  • Oxidation-Reduction
  • Titanium / chemistry*

Substances

  • Blood Glucose
  • titanium dioxide
  • Copper
  • Titanium
  • cuprous oxide