Quinolone resistance mechanisms in Salmonella enterica serovars Hadar, Kentucky, Virchow, Schwarzengrund, and 4,5,12:i:-, isolated from humans in Switzerland, and identification of a novel qnrD variant, qnrD2, in S. Hadar

Helga Abgottspon; Katrin Zurfluh; Magdalena Nüesch-Inderbinen; Herbert Hächler; Roger Stephan

doi:10.1128/AAC.02404-14

Quinolone resistance mechanisms in Salmonella enterica serovars Hadar, Kentucky, Virchow, Schwarzengrund, and 4,5,12:i:-, isolated from humans in Switzerland, and identification of a novel qnrD variant, qnrD2, in S. Hadar

Antimicrob Agents Chemother. 2014 Jun;58(6):3560-3. doi: 10.1128/AAC.02404-14. Epub 2014 Apr 14.

Authors

Helga Abgottspon¹, Katrin Zurfluh¹, Magdalena Nüesch-Inderbinen¹, Herbert Hächler¹, Roger Stephan²

Affiliations

¹ Institute for Food Safety and Hygiene, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
² Institute for Food Safety and Hygiene, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland [email protected].

Abstract

Human isolates of Salmonella enterica serovars Hadar, Kentucky, Virchow, Schwarzengrund, and the monophasic variant of S. Typhimurium, Salmonella enterica subsp. enterica serovar 4,5,12:i:- were examined for mutations within the quinolone resistance target genes gyrA, gyrB, parC, and parE and for plasmid-mediated resistance genes. Differences were observed among the serovars. A novel variant of qnrD, qnrD2, was detected in an S. Hadar isolate.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology*
Base Sequence
DNA Gyrase / genetics*
Drug Resistance, Bacterial / genetics*
Humans
Microbial Sensitivity Tests
Nalidixic Acid / pharmacology
Plasmids / genetics
Quinolones / pharmacology*
Salmonella enterica / drug effects
Salmonella enterica / genetics*
Sequence Analysis, DNA
Serogroup
Switzerland

Substances

Anti-Bacterial Agents
Quinolones
Nalidixic Acid
DNA Gyrase

Associated data

GENBANK/KF055448
GENBANK/KJ158441