Abstract
One new naphthalene derivative, 1,8-dihydroxynaphthol-1-O-α-l-rhamnopyranoside (1), together with one known α-dibenzopyrone, alternariol (2), and five xanthones (3-7) were isolated from the sponge-derived fungus Arthrinium sp. ZSDS1-F3. All the isolated compounds (1-7) were established by comprehensive analysis of the spectral data, especially 1D and 2D NMR (HMQC and HMBC) spectra. In the primary bioassays, compound 3 exhibited moderate COX-2 inhibition, with IC50 values of 12.2 μM.
Keywords:
Arthrinium sp.; naphthalene glycoside; secondary metabolite; sponge.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Ascomycota / chemistry*
-
Cyclooxygenase 2 Inhibitors / chemistry
-
Cyclooxygenase 2 Inhibitors / isolation & purification*
-
Cyclooxygenase 2 Inhibitors / pharmacology
-
Glycosides / chemistry
-
Glycosides / isolation & purification*
-
Glycosides / pharmacology
-
Inhibitory Concentration 50
-
Molecular Structure
-
Naphthols / chemistry
-
Naphthols / isolation & purification*
-
Naphthols / pharmacology
-
Nuclear Magnetic Resonance, Biomolecular
-
Porifera / microbiology*
-
Xanthones / chemistry
-
Xanthones / isolation & purification*
-
Xanthones / pharmacology
Substances
-
1,8-dihydroxynaphthol-1-O-alpha-rhamnopyranoside
-
Cyclooxygenase 2 Inhibitors
-
Glycosides
-
Naphthols
-
Xanthones