Lipid droplet biogenesis

Florian Wilfling; Joel T Haas; Tobias C Walther; Robert V Farese Jr

doi:10.1016/j.ceb.2014.03.008

Lipid droplet biogenesis

Curr Opin Cell Biol. 2014 Aug:29:39-45. doi: 10.1016/j.ceb.2014.03.008. Epub 2014 Apr 14.

Authors

Florian Wilfling¹, Joel T Haas², Tobias C Walther³, Robert V Farese Jr⁴

Affiliations

¹ Yale School of Medicine, Department of Cell Biology, New Haven, CT, USA.
² Gladstone Institute of Cardiovascular Disease, San Francisco, CA, USA; Department of Biochemistry and Biophysics, University of California-San Francisco, CA, USA.
³ Yale School of Medicine, Department of Cell Biology, New Haven, CT, USA. Electronic address: [email protected].
⁴ Gladstone Institute of Cardiovascular Disease, San Francisco, CA, USA; Department of Biochemistry and Biophysics, University of California-San Francisco, CA, USA; Department of Medicine, University of California-San Francisco, CA, USA. Electronic address: [email protected].

Abstract

Lipid droplets (LDs) are found in most cells, where they play central roles in energy and membrane lipid metabolism. The de novo biogenesis of LDs is a fascinating, yet poorly understood process involving the formation of a monolayer bound organelle from a bilayer membrane. Additionally, large LDs can form either by growth of existing LDs or by the combination of smaller LDs through several distinct mechanisms. Here, we review recent insights into the molecular process governing LD biogenesis and highlight areas of incomplete knowledge.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Biological Transport
Humans
Lipid Metabolism*
Lipids* / chemistry
Organelles / metabolism
Transport Vesicles / metabolism*

Substances

Lipids

Abstract

Publication types

MeSH terms

Substances

Grants and funding