Silk protein lithography as a route to fabricate sericin microarchitectures

Adv Mater. 2014 Jul 9;26(26):4431-7. doi: 10.1002/adma.201400777. Epub 2014 Apr 16.

Abstract

Photolithographic fabrication via a "silk sericin photoresist" is used to form precise protein microstructures directly and rapidly on a variety of substrates. High-resolution and fidelity architectures in two and three dimensions with line widths down to 1 μm are formed. Photo-crosslinked protein structures provide structural iridescence and guide cell adhesion with precise spatial control.

Keywords: micropatterning; photolithography; protein photoresist; sericin; silk.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bombyx
  • Cells, Cultured
  • Mice
  • Microscopy, Atomic Force
  • Microscopy, Electron, Scanning
  • Microtechnology / methods*
  • Nanostructures / chemistry
  • Osteoblasts / cytology
  • Photochemical Processes
  • Printing / methods*
  • Sericins / chemistry*
  • Silk / chemistry*
  • Spectroscopy, Fourier Transform Infrared
  • Tissue Scaffolds / chemistry

Substances

  • Sericins
  • Silk