Problems of the perspective of geoinformational systems (GIS) use for improvement of epidemiologic control of infectious diseases including during mass events are examined. A scheme of creation of the decision making support system (DMSS) is proposed, the system is based on GIS, has general primary data and analytical-prognostic tool base including subsystems: real-time primary information intake, information analysis, epizootic and epidemic activity prognosis on the certain territories and the federal level. Specialized personnel training, creation of infrastructure for DMSS functioning in primary Federal Service of Surveillance for Protection of Consumers Rights and Human Welfare units are designated as priority tasks.