Comparative uptake of ¹⁸F-FEN-DPAZn2, ¹⁸F-FECH, ¹⁸F-fluoride, and ¹⁸F-FDG in fibrosarcoma and aseptic inflammation

Appl Radiat Isot. 2014 Aug:90:158-64. doi: 10.1016/j.apradiso.2014.03.030. Epub 2014 Apr 5.

Abstract

The aim of this study is to evaluate uptake of 2-(18)F-fluoroethyl-bis(zinc(II)-dipicolylamine) ((18)F-FEN-DPAZn2) as a promising cell death imaging agent, a choline analog (18)F-fluoroethylcholine ((18)F-FECH), (18)F-fluoride as a bone imaging agent, and a glucose analog 2-(18)F-fluoro-2-deoxy-d-glucose ((18)F-FDG) in the combined S180 fibrosarcoma and turpentine-induced inflammation mice models. The results showed that (18)F-FDG had the highest tumor-to-blood uptake ratio and tumor-to-muscle ratio, and high inflammation-to-blood ratio and inflammation-to-muscle ratio. (18)F -FECH showed moderate tumor-to-blood ratio and tumor-to-muscle ratio, and low inflammation-to-blood ratio and inflammation-to-muscle ratio. However, accumulation of (18)F FEN-DPAZn2 in tumor was similar to that in normal muscle. Also, (18)F-FEN-DPAZn2 and (18)F-fluoride exhibited the best selectivity to inflammation. (18)F-FECH positron emission tomography (PET) imaging demonstrates some advantages over (18)F-FDG PET for the differentiation of tumor from inflammation. (18)F FEN-DPAZn2 and (18)F-fluoride can be used for PET imaging of aseptic inflammation.

Keywords: (18)F-FDG; (18)F-FECH; (18)F-FEN-DPAZn2; (18)F-Fluoride; Inflammation; Tumor.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bacterial Infections / chemically induced
  • Bacterial Infections / diagnostic imaging
  • Bacterial Infections / metabolism*
  • Cell Line, Tumor
  • Choline / analogs & derivatives*
  • Choline / pharmacokinetics
  • Diagnosis, Differential
  • Female
  • Fibrosarcoma / diagnostic imaging
  • Fibrosarcoma / metabolism*
  • Fluorides / pharmacokinetics
  • Fluorine Radioisotopes / pharmacokinetics*
  • Fluorodeoxyglucose F18 / pharmacokinetics*
  • Inflammation / chemically induced
  • Inflammation / diagnostic imaging
  • Inflammation / metabolism*
  • Male
  • Metabolic Clearance Rate
  • Mice
  • Organ Specificity
  • Organometallic Compounds / pharmacokinetics*
  • Picolinic Acids / pharmacokinetics*
  • Radionuclide Imaging
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Tissue Distribution
  • Turpentine

Substances

  • Fluorine Radioisotopes
  • Organometallic Compounds
  • Picolinic Acids
  • bis-dipicolylamine-Zinc(II)
  • Fluorodeoxyglucose F18
  • fluoroethylcholine
  • Choline
  • Fluorides
  • Turpentine