Complete nucleotide sequence of two multidrug-resistant IncR plasmids from Klebsiella pneumoniae

Antimicrob Agents Chemother. 2014 Jul;58(7):4207-10. doi: 10.1128/AAC.02773-13. Epub 2014 Apr 21.

Abstract

We report here the complete nucleotide sequence of two IncR replicons encoding multidrug resistance determinants, including β-lactam (blaDHA-1, blaSHV-12), aminoglycoside (aphA1, strA, strB), and fluoroquinolone (qnrB4, aac6'-1b-cr) resistance genes. The plasmids have backbones that are similar to each other, including the replication and stability systems, and contain a wide variety of transposable elements carrying known antibiotic resistance genes. This study confirms the increasing clinical importance of IncR replicons as resistance gene carriers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminoglycosides / pharmacology
  • Anti-Bacterial Agents / pharmacology
  • Base Sequence
  • DNA Transposable Elements / genetics*
  • Drug Resistance, Multiple, Bacterial / genetics
  • Fluoroquinolones / pharmacology
  • Genes, MDR / genetics*
  • Klebsiella pneumoniae / genetics*
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • R Factors / genetics*
  • Sequence Analysis, DNA
  • beta-Lactam Resistance / genetics
  • beta-Lactamases / genetics

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • DNA Transposable Elements
  • Fluoroquinolones
  • beta-Lactamases

Associated data

  • GENBANK/KF793937
  • GENBANK/KF954150