3D graphene foams decorated by CuO nanoflowers for ultrasensitive ascorbic acid detection

Ye Ma; Minggang Zhao; Bin Cai; Wei Wang; Zhizhen Ye; Jingyun Huang

doi:10.1016/j.bios.2014.03.064

3D graphene foams decorated by CuO nanoflowers for ultrasensitive ascorbic acid detection

Biosens Bioelectron. 2014 Sep 15:59:384-8. doi: 10.1016/j.bios.2014.03.064. Epub 2014 Apr 13.

Authors

Ye Ma¹, Minggang Zhao¹, Bin Cai¹, Wei Wang¹, Zhizhen Ye², Jingyun Huang³

Affiliations

¹ State Key Laboratory of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China.
² State Key Laboratory of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China; Cyrus Tang Center for Sensor Materials and Applications, Zhejiang University, Hangzhou 310058, China.
³ State Key Laboratory of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China; Cyrus Tang Center for Sensor Materials and Applications, Zhejiang University, Hangzhou 310058, China. Electronic address: [email protected].

PMID: 24755255
DOI: 10.1016/j.bios.2014.03.064

Abstract

When the in vitro research works of biosensing begin to mimic in vivo conditions, some certain three-dimensional (3D) structures of biosensors are needed to accommodate biomolecules, bacteria or even cells to resemble the in vivo 3D environment. To meet this end, a novel method of synthesizing CuO nanoflowers on the 3D graphene foam (GF) was first demonstrated. The 3DGF/CuO nanoflowers composite was used as a monolithic free-standing 3D biosensor for electrochemical detection of ascorbic acid (AA). The 3D conductive structure of the GF is favorable for current collection, mass transport and loading bioactive chemicals. And CuO nanoflowers further increase the active surface area and catalyze the redox of AA. Thus, all these features endows 3DGF/CuO composite with outstanding biosensing properties such as an ultrahigh sensitivity of 2.06 mA mM(-1) cm(-2) to AA at 3 s response time.

Keywords: Ascorbic acid; Biosensor; Copper oxide; Free-standing; Graphene foam; Three dimensions.

Publication types

Evaluation Study
Research Support, Non-U.S. Gov't

MeSH terms

Ascorbic Acid / analysis*
Biosensing Techniques / methods*
Copper / chemistry*
Electrochemical Techniques
Electrodes
Graphite / chemistry*
Limit of Detection
Nanostructures / chemistry*
Nanostructures / ultrastructure

Substances

Graphite
Copper
Ascorbic Acid
cupric oxide