[A case of urachal carcinoma with multiple lung metastases treated by TS-1/CDDP chemotherapy]

Hinyokika Kiyo. 2014 Mar;60(3):147-50.
[Article in Japanese]

Abstract

A 67-year-old woman presented with macroscopic hematuria and lower abdominal pain. Cystoscopy revealed a broad-stalk non-papillary tumor at the bladder dome. Computed tomography (CT) showed a tumor extending from the umbilicus to the bladder dome, together with multiple lung metastases. Serum carcinoembryonic antigen and cancer antigen (CA19-9) levels were elevated at 7.0 ng/ml and 180 U/ml, respectively. Transurethral resection of the tumor was performed and histopathology revealed adenocarcinoma. Therefore, the tumor was diagnosed as a stage IVB (Sheldon's category) urachal carcinoma. En bloc segmental resection of the urachal carcinoma with the bladder dome was performed, followed by chemotherapy with tegafur, gimestat, and otastat potassium (TS-1) and cisplatin. The disease remained stable for 8 months. However, a follow up CT scan after 11 chemotherapy cycles showed progression of the lung metastases. In spite of the change to a second-line gemcitabine and cisplatin chemotherapy regimen, the disease continued to progress after 4 cycles.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adenocarcinoma / drug therapy*
  • Adenocarcinoma / pathology*
  • Aged
  • Antigens, Tumor-Associated, Carbohydrate / blood
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Carcinoembryonic Antigen / blood
  • Drug Combinations
  • Female
  • Humans
  • Lung Neoplasms / drug therapy*
  • Lung Neoplasms / secondary*
  • Oxonic Acid / administration & dosage
  • Tegafur / administration & dosage
  • Urinary Bladder Neoplasms / drug therapy*
  • Urinary Bladder Neoplasms / pathology*

Substances

  • Antigens, Tumor-Associated, Carbohydrate
  • Carcinoembryonic Antigen
  • Drug Combinations
  • carbohydrate antigen 199, human
  • S 1 (combination)
  • Tegafur
  • Oxonic Acid

Supplementary concepts

  • Urachal cancer