Mast cell degranulating peptide forms voltage gated and cation-selective channels in lipid bilayers

Biochem Biophys Res Commun. 1989 Aug 30;163(1):155-60. doi: 10.1016/0006-291x(89)92113-x.

Abstract

Mast cell degranulating peptide, a toxin of bee venom, is a polypeptide composed of 22 amino acids. Exposure of the asolectin bilayer to the peptide results in the formation of channels that are more permeable to K+ than Cl-. These channels are activated when the voltage of the cis side, to which the peptide is added, is made positive.

MeSH terms

  • Bee Venoms / analysis
  • Electric Conductivity
  • In Vitro Techniques
  • Ion Channels / physiology*
  • Lipid Bilayers
  • Mast Cells / physiology*
  • Membrane Potentials
  • Peptides / physiology*
  • Phosphatidylcholines

Substances

  • Bee Venoms
  • Ion Channels
  • Lipid Bilayers
  • Peptides
  • Phosphatidylcholines
  • mast cell degranulating peptide