Methicillin-susceptible Staphylococcus aureus CC398: first description in prosthetic joint infection and genetic background comparison with nasal carriage isolates

J Infect Chemother. 2014 Jun;20(6):394-6. doi: 10.1016/j.jiac.2014.03.007. Epub 2014 Apr 22.

Abstract

Few reports described infections with CC398 methicillin-susceptible Staphylococcus aureus (MSSA). We compared the genetic background of CC398 MSSA strains from nasal carriage and knee arthroplasty infection. DNA microarray analysis shows acquisition of particular adhesin, iron capture system and immune defense evasion mechanisms. These characteristics could explain pathogenesis in this type of infection.

Keywords: DNA microarray; Livestock associated Staphylococcus aureus CC398; Prosthetic-related infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Agriculture
  • Carrier State / microbiology*
  • DNA, Bacterial / analysis
  • DNA, Bacterial / genetics
  • Female
  • France
  • Humans
  • Male
  • Methicillin-Resistant Staphylococcus aureus
  • Middle Aged
  • Nasal Cavity / microbiology*
  • Prosthesis-Related Infections / microbiology*
  • Staphylococcus aureus / classification
  • Staphylococcus aureus / genetics
  • Staphylococcus aureus / isolation & purification*
  • Young Adult

Substances

  • DNA, Bacterial