Biological activities of new monohydroxylated brassinosteroid analogues with a carboxylic group in the side chain

Miroslav Kvasnica; Jana Oklestkova; Vaclav Bazgier; Lucie Rarova; Karel Berka; Miroslav Strnad

doi:10.1016/j.steroids.2014.04.007

Biological activities of new monohydroxylated brassinosteroid analogues with a carboxylic group in the side chain

Steroids. 2014 Jul:85:58-64. doi: 10.1016/j.steroids.2014.04.007. Epub 2014 Apr 21.

Authors

Miroslav Kvasnica¹, Jana Oklestkova², Vaclav Bazgier³, Lucie Rarova¹, Karel Berka⁴, Miroslav Strnad¹

Affiliations

¹ Laboratory of Growth Regulators, Centre of the Region Haná for Biotechnological and Agricultural Research, Institute of Experimental Botany ASCR & Palacký University, Šlechtitelů 11, 78371 Olomouc, Czech Republic.
² Laboratory of Growth Regulators, Centre of the Region Haná for Biotechnological and Agricultural Research, Institute of Experimental Botany ASCR & Palacký University, Šlechtitelů 11, 78371 Olomouc, Czech Republic. Electronic address: [email protected].
³ Laboratory of Growth Regulators, Centre of the Region Haná for Biotechnological and Agricultural Research, Institute of Experimental Botany ASCR & Palacký University, Šlechtitelů 11, 78371 Olomouc, Czech Republic; Department of Physical Chemistry, Faculty of Science, Palacký University, tř. 17. Listopadu 12, 77146 Olomouc, Czech Republic.
⁴ Regional Centre of Advanced Technologies and Material, Department of Physical Chemistry, Faculty of Science, Palacký University, 17. Listopadu 12, 77146 Olomouc, Czech Republic.

PMID: 24769247
DOI: 10.1016/j.steroids.2014.04.007

Abstract

Thirteen monohydroxylated brassinosteroids analogues were synthesized and tested for their biological activity in plant and animal systems. The cytotoxic activity of the products was studied using human normal and cancer cell lines with 28-homocastasterone as positive control, their brassinolide type activity was established using the bean second-internode test with 24-epibrassinolide as standard.

Keywords: Anticancer activity; Brassinosteroids; Molecular docking; Organic synthesis; Plant bioassays; Receptor kinase BRI1.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Brassinosteroids / administration & dosage
Brassinosteroids / chemical synthesis*
Cell Line, Tumor
Cell Proliferation / drug effects
Cholestanols / administration & dosage
Cholestanols / chemical synthesis*
Cytotoxins / administration & dosage
Cytotoxins / chemical synthesis*
Humans
Molecular Structure
Steroids, Heterocyclic / administration & dosage
Structure-Activity Relationship

Substances

Brassinosteroids
Cholestanols
Cytotoxins
Steroids, Heterocyclic
brassinolide