Lewis acid/Brönsted acid mediated benz-annulation of thiophenes and electron-rich arenes

Org Lett. 2014 May 16;16(10):2720-3. doi: 10.1021/ol501006t. Epub 2014 Apr 28.

Abstract

A facile preparation of benz-annulated heterocycles were achieved at rt involving a Lewis acid/Brönsted acid mediated annulation of heterocycles using 2,5-dimethoxytetrahydrofuran as a four-carbon synthon. The benz-/naphth-annulation was found to be successful with electron-rich arenes as well.