VEGF-A clinical significance in gastric cancers: immunohistochemical analysis of a wide Italian cohort

E Lastraioli; L Boni; M R Romoli; S Crescioli; A Taddei; S Beghelli; A Tomezzoli; C Vindigni; L Saragoni; L Messerini; M Bernini; L Bencini; E Giommoni; G Freschi; F Di Costanzo; A Scarpa; P Morgagni; M Farsi; F Roviello; G De Manzoni; P Bechi; A Arcangeli; Gruppo Italiano di Ricerca Cancro Gastrico (GIRCG)

doi:10.1016/j.ejso.2014.03.028

VEGF-A clinical significance in gastric cancers: immunohistochemical analysis of a wide Italian cohort

Eur J Surg Oncol. 2014 Oct;40(10):1291-8. doi: 10.1016/j.ejso.2014.03.028. Epub 2014 Apr 12.

Authors

E Lastraioli¹, L Boni², M R Romoli¹, S Crescioli¹, A Taddei³, S Beghelli⁴, A Tomezzoli⁵, C Vindigni⁶, L Saragoni⁷, L Messerini¹, M Bernini⁸, L Bencini⁸, E Giommoni⁹, G Freschi³, F Di Costanzo⁹, A Scarpa⁴, P Morgagni¹⁰, M Farsi⁸, F Roviello¹¹, G De Manzoni¹², P Bechi³, A Arcangeli¹³; Gruppo Italiano di Ricerca Cancro Gastrico (GIRCG)

Affiliations

¹ Department of Clinical and Experimental Medicine, University of Florence, Largo GA Brambilla 3, 50134 Florence, Italy.
² Clinical Trials Coordinating Center, Azienda Ospedaliero-Universitaria Careggi/Istituto Toscano Tumori, Largo GA Brambilla 3, 50134 Florence, Italy.
³ Surgery and Translational Medicine, University of Florence, Largo GA Brambilla 3, 50134 Florence, Italy.
⁴ Department of Pathology and Diagnostics, University of Verona, Piazzale LA Scuro 10, 37134 Verona, Italy.
⁵ Pathology Division, Borgo Trento Hospital, Piazzale A Stefani 1, 37134 Verona, Italy.
⁶ Pathology Division, Azienda Ospedaliero-Universitaria Senese, Viale M Bracci 16, 53100 Siena, Italy.
⁷ Pathology Division, Morgagni-Pierantoni Hospital, Via C Forlanini 34, 47121 Forlì, Italy.
⁸ General Surgery and Surgical Oncology, Azienda Ospedaliero-Universitaria Careggi, Largo GA Brambilla 3, 50134 Florence, Florence, Italy.
⁹ Medical Oncology, Azienda Ospedaliero-Universitaria Careggi, Largo GA Brambilla 3, 50134 Florence, Florence, Italy.
¹⁰ General Surgery, Morgagni-Pierantoni Hospital, Via C Forlanini 34, 47121 Forlì, Italy.
¹¹ Department of General Surgery and Oncology, University of Siena, Viale M Bracci 16, 53100 Siena, Italy.
¹² Division of Surgery, University of Verona, Piazzale LA Scuro 10, 37134 Verona, Italy.
¹³ Department of Clinical and Experimental Medicine, University of Florence, Largo GA Brambilla 3, 50134 Florence, Italy. Electronic address: [email protected].

PMID: 24784776
DOI: 10.1016/j.ejso.2014.03.028

Abstract

Purpose: The clinical significance of VEGF-A expression in gastric cancer (GC) has been reported with contradicting results. We analyzed the expression and clinical significance of VEGF-A in a wide Italian cohort of GC specimens.

Methods: VEGF-A expression was tested by immunohistochemistry in 507 patients with GC of all clinical stages. The impact of VEGF-A on overall survival (OS) was evaluated in conjunction with clinical and pathological parameters.

Results: In the Italian cohort we studied VEGF-A was not an independent prognostic factor neither at the univariate nor at multivariate analysis.

Conclusions: Although frequently expressed, in our study VEGF-A was not able to discriminate between groups of patients with different risk.

Keywords: Gastric cancer; Immunohistochemistry; Prognostic markers; VEGF-A.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenocarcinoma / metabolism*
Adenocarcinoma / mortality
Adult
Aged
Cohort Studies
Female
Humans
Immunohistochemistry
Italy
Logistic Models
Male
Middle Aged
Prognosis
Stomach Neoplasms / metabolism*
Stomach Neoplasms / mortality
Vascular Endothelial Growth Factor A / metabolism*

Substances

VEGFA protein, human
Vascular Endothelial Growth Factor A

Grants and funding

06-0491/AICR_/Worldwide Cancer Research/United Kingdom