Mild Rh(III)-catalyzed direct C-H bond arylation of (hetero)arenes with arylsilanes in aqueous media

Ming-Zhu Lu; Ping Lu; Yun-He Xu; Teck-Peng Loh

doi:10.1021/ol500754h

Mild Rh(III)-catalyzed direct C-H bond arylation of (hetero)arenes with arylsilanes in aqueous media

Org Lett. 2014 May 16;16(10):2614-7. doi: 10.1021/ol500754h. Epub 2014 Apr 30.

Authors

Ming-Zhu Lu¹, Ping Lu, Yun-He Xu, Teck-Peng Loh

Affiliation

¹ Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China , Hefei, 230026, China.

PMID: 24785121
DOI: 10.1021/ol500754h

Abstract

An efficient rhodium(III)-catalyzed C-H bond activation and further direct arylation of (hetero)arenes with organosilanes in aqueous media was developed. This reaction shows good substrate scope and excellent functional group compatibility and gives the products in good yields with excellent regioselectivity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Combinatorial Chemistry Techniques
Heterocyclic Compounds / chemical synthesis*
Heterocyclic Compounds / chemistry
Magnetic Resonance Spectroscopy
Molecular Structure
Rhodium / chemistry*
Silanes / chemistry*
Water

Substances

Heterocyclic Compounds
Silanes
Water
Rhodium