Abstract
Chemical synthesis of proteins, especially those with post-translational modifications, has offered new opportunities to study the protein structure-function relationship. In the past four years, we have developed the serine/threonine ligation (STL), which involves the chemoselective reaction between peptide salicylaldehyde esters and peptides with N-terminal serine or threonine. The method has been successfully applied to the synthesis of both linear and cyclic peptides/proteins.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acid Anhydride Hydrolases / metabolism
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Acylphosphatase
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Amino Acid Sequence
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Chemistry Techniques, Synthetic / methods*
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Erythrocytes / enzymology
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Esters / chemistry
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Molecular Sequence Data
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Mucin-1 / metabolism
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Peptides, Cyclic / chemical synthesis
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Peptides, Cyclic / chemistry
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Serine / chemical synthesis*
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Serine / chemistry
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Threonine / chemical synthesis*
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Threonine / chemistry
Substances
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Esters
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Mucin-1
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Peptides, Cyclic
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Threonine
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Serine
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Acid Anhydride Hydrolases