Abstract
Two new neo-clerodane diterpenoids, teucvisins A and B (1, 2), and three new 19-nor-neoclerodane diterpenoids, teucvisins C-E (3-5), together with ten known constituents (6-15) were isolated from the whole plants of Teucrium viscidum. All the isolates were evaluated for their inhibitory activities of lipopolysaccharide (LPS)-induced nitric oxide production in RAW264.7 macrophages. The results indicated that compounds 11 and 15 showed moderate inhibition with an IC50 value of 21.9 and 22.4 µM, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Diterpenes, Clerodane / chemistry
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Diterpenes, Clerodane / isolation & purification
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Diterpenes, Clerodane / pharmacology*
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Dose-Response Relationship, Drug
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Lipopolysaccharides / antagonists & inhibitors
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Lipopolysaccharides / pharmacology
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Macrophages / drug effects*
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Macrophages / metabolism
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Mice
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Molecular Structure
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Nitric Oxide / antagonists & inhibitors
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Nitric Oxide / biosynthesis
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Structure-Activity Relationship
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Teucrium / chemistry*
Substances
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Diterpenes, Clerodane
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Lipopolysaccharides
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Nitric Oxide