Abstract
Five new bromopyrrole alkaloids, 2-bromokeramadine (1), 2-bromo-9,10-dihydrokeramadine (2), tauroacidins C (3) and D (4), and mukanadin G (5), were isolated from an Okinawan marine sponge Agelas sp. The structures of 1-5 were elucidated on the basis of spectroscopic data and conformational analysis. Mukanadin G (5) has a tricyclic skeleton consisting of a fused tetrahydrobenzaminoimidazole and 2,5-dioxopyrrolidine moieties. Antimicrobial activities of 1-3, and 5 as well as three related known bromopyrrole alkaloids, keramadine (6), tauroacidin A (7), and taurodispacamide A (8) were evaluated.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Alkaloids / chemistry
-
Alkaloids / isolation & purification
-
Alkaloids / pharmacology*
-
Animals
-
Anti-Bacterial Agents / chemistry
-
Anti-Bacterial Agents / isolation & purification
-
Anti-Bacterial Agents / pharmacology*
-
Antifungal Agents / chemistry
-
Antifungal Agents / isolation & purification
-
Antifungal Agents / pharmacology*
-
Bacteria / drug effects
-
Dose-Response Relationship, Drug
-
Fungi / drug effects
-
Hydrocarbons, Brominated / chemistry
-
Hydrocarbons, Brominated / isolation & purification
-
Hydrocarbons, Brominated / pharmacology*
-
Microbial Sensitivity Tests
-
Molecular Structure
-
Porifera / chemistry*
-
Pyrroles / chemistry
-
Pyrroles / isolation & purification
-
Pyrroles / pharmacology*
-
Structure-Activity Relationship
Substances
-
Alkaloids
-
Anti-Bacterial Agents
-
Antifungal Agents
-
Hydrocarbons, Brominated
-
Pyrroles