Abstract
Fifty-eight mite-allergic asthmatic patients ages 15 to 22 years were examined. Low respiratory threshold to acetyl-choline (RT-Ach), high maximal histamine release (HR) by mite and anti-IgE, high serum IgE levels and high eosinophil counts were highly associated with the severity of asthma. RT-Ach correlated inversely with HR to mite and anti-IgE. The maximal histamine release from leukocyte caused by anti-IgE also correlated highly with the severity of asthma.
MeSH terms
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Adolescent
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Adult
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Antibodies, Anti-Idiotypic / pharmacology
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Antibody Specificity
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Asthma / physiopathology*
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Bronchial Provocation Tests
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Eosinophils
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Female
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Histamine Release / drug effects
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Humans
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Immunoglobulin E / analysis
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Immunoglobulin E / immunology
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Immunoglobulin E / pharmacology
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Leukocyte Count
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Male
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Nasal Provocation Tests
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Respiratory Hypersensitivity / physiopathology
Substances
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Antibodies, Anti-Idiotypic
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anti-IgE antibodies
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Immunoglobulin E