Abstract
Inhibition of the synthesis of endothelium derived relaxing factor by NG-monomethyl-L-arginine, a competitive inhibitor of the synthesis of nitric oxide from L-arginine, enhances hypoxic pulmonary vasoconstriction in pulmonary artery rings and isolated, Krebs albumin perfused rat lungs. L-arginine rapidly reduces hypoxic vasoconstriction, particularly in lungs treated with NG-monomethyl-L-arginine. Following administration of NG-monomethyl-L-arginine, bradykinin-induced vasodilatation is inhibited (p less than 0.01) and a bradykinin-induced vasoconstriction develops (p less than 0.001). NG-monomethyl-L-arginine does not significantly diminish acetylcholine-induced vasodilatation in the isolated lung. NG-monomethyl-L-arginine causes an endothelium-dependent vasoconstriction in pulmonary artery rings.
Publication types
-
Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
-
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / pharmacology
-
Acetylcholine / pharmacology
-
Angiotensin II / pharmacology
-
Animals
-
Arginine / pharmacology
-
Blood Pressure / drug effects
-
Bradykinin / pharmacology
-
Hypoxia / physiopathology
-
In Vitro Techniques
-
Male
-
Muscle, Smooth, Vascular / drug effects
-
Muscle, Smooth, Vascular / physiology*
-
Muscle, Smooth, Vascular / physiopathology
-
Nitric Oxide / antagonists & inhibitors*
-
Nitric Oxide / biosynthesis
-
Norepinephrine / pharmacology
-
Pulmonary Artery / drug effects
-
Pulmonary Artery / physiology*
-
Pulmonary Artery / physiopathology
-
Rats
-
Rats, Inbred Strains
-
Stereoisomerism
-
Vasoconstriction* / drug effects
-
omega-N-Methylarginine
Substances
-
Angiotensin II
-
omega-N-Methylarginine
-
Nitric Oxide
-
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
-
Arginine
-
Acetylcholine
-
Bradykinin
-
Norepinephrine