Controlling leucine-zipper partner recognition in cells through modification of a-g interactions

Yusuke Azuma; Tim Kükenshöner; Guangyong Ma; Jun-ichiro Yasunaga; Miki Imanishi; Gen Tanaka; Ikuhiko Nakase; Takahiro Maruno; Yuji Kobayashi; Katja M Arndt; Masao Matsuoka; Shiroh Futaki

doi:10.1039/c4cc00555d

Controlling leucine-zipper partner recognition in cells through modification of a-g interactions

Chem Commun (Camb). 2014 Jun 18;50(48):6364-7. doi: 10.1039/c4cc00555d.

Authors

Yusuke Azuma¹, Tim Kükenshöner, Guangyong Ma, Jun-ichiro Yasunaga, Miki Imanishi, Gen Tanaka, Ikuhiko Nakase, Takahiro Maruno, Yuji Kobayashi, Katja M Arndt, Masao Matsuoka, Shiroh Futaki

Affiliation

¹ Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan. [email protected].

PMID: 24803110
DOI: 10.1039/c4cc00555d

Abstract

By focusing on the a-g interactions, successful design and selection were accomplished to obtain a leucine-zipper segment that discriminates the appropriate partner over another that provides very similar patterns of electrostatic interactions.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Basic-Leucine Zipper Transcription Factors / chemistry
Basic-Leucine Zipper Transcription Factors / metabolism*
HeLa Cells
Humans
Peptides / chemistry
Peptides / metabolism*
Static Electricity

Substances

Basic-Leucine Zipper Transcription Factors
Peptides