Abstract
Among the cytokines tested here (IL-2, IL-3, IL-4, IL-5, IL-6, granulocyte colony stimulating factor (G-CSF), granulocyte/macrophage colony stimulating factor (GM-CSF), interferon-alpha (IFN-alpha), interferon-beta (IFN-beta) and interferon-gamma (IFN-gamma] only interleukin 1(IL-1) augmented HIV-long terminal repeat(LTR) directed chloramphenicol acetyl transferase(CAT) activity in protein kinase C(PKC)-independent manner. However, a stimulation by IL-1 was not as efficient as that due to tumor necrosis factor and the HIV production was not significant. IL-1 was not cytotoxic to MOLT-4/HIV cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / pharmacology
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Biological Factors / pharmacology*
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Cell Division / drug effects
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Cell Line
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Chloramphenicol O-Acetyltransferase / genetics
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Cytokines
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Gene Expression / drug effects*
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Genes, Viral / drug effects*
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Growth Substances / pharmacology
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HIV / drug effects
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HIV / genetics*
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HIV / growth & development
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Humans
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Interferons / pharmacology
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Interleukin-1 / pharmacology*
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Interleukins / pharmacology
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Kinetics
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Repetitive Sequences, Nucleic Acid
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Staurosporine
Substances
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Alkaloids
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Biological Factors
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Cytokines
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Growth Substances
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Interleukin-1
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Interleukins
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Interferons
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Chloramphenicol O-Acetyltransferase
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Staurosporine