A meta-analysis of P2X7 gene-762T/C polymorphism and pulmonary tuberculosis susceptibility

Lingling Yi; Dan Cheng; Huimin Shi; Xiaorong Huo; Kan Zhang; Guohua Zhen

doi:10.1371/journal.pone.0096359

A meta-analysis of P2X7 gene-762T/C polymorphism and pulmonary tuberculosis susceptibility

PLoS One. 2014 May 8;9(5):e96359. doi: 10.1371/journal.pone.0096359. eCollection 2014.

Authors

Lingling Yi¹, Dan Cheng¹, Huimin Shi¹, Xiaorong Huo¹, Kan Zhang¹, Guohua Zhen¹

Affiliation

¹ Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, and Key Laboratory of Respiratory Diseases, Ministry of Health, Wuhan, Hubei, China.

Abstract

Aim: We performed a comprehensive meta-analysis to determine the association between P2X7 -762T/C polymorphism and pulmonary tuberculosis susceptibility.

Methodology: Based on comprehensive searches of the PubMed, SCI, Elsevier, China National Knowledge Infrastructure (CNKI) and Wanfang Database, we identified eligible studies about the association between P2X7 -762T/C polymorphism and pulmonary tuberculosis risk. Pooled odds ratio (ORs) and 95% confidence intervals (95%CIs) were calculated in random-effects model.

Results: A total of 2207 tuberculosis cases and 2220 controls in 8 case-control studies were included in this meta-analysis. Allele model (C vs. T: p = 0.15; OR = 0.83, 95% CI = 0.65-1.07), homozygous model (CC vs. TT: p = 0.23; OR = 0.73, 95% CI = 0.44 to 1.22), and heterozygous model (CT vs. TT: p = 0.57; OR = 0.92, 95% CI = 0.68 to 1.24) did not show increased risk of developing pulmonary tuberculosis. Similarly, dominant model (CC+CT vs. TT: p = 0.32; OR = 0.84, 95% CI = 0.59 to 1.19) and recessive model (CC vs. CT+TT: p = 0.08; OR = 0.77, 95% CI = 0.57 to 1.04) failed to show increased risk of developing pulmonary tuberculosis. Subgroup analysis by ethnicity did not detect any significant association between P2X7-762T/C polymorphism and pulmonary tuberculosis susceptibility.

Conclusions: P2X7 -762T/C gene polymorphism is not associated with pulmonary tuberculosis susceptibility.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Genetic Predisposition to Disease*
Genotype
Humans
Polymorphism, Single Nucleotide
Receptors, Purinergic P2X7 / genetics*
Tuberculosis, Pulmonary / genetics*

Substances

Receptors, Purinergic P2X7

Grants and funding

This study was supported by National Natural Science Foundation of China Grant 81170022, and National Key Technology R&D Program of the 12th Five-year Development Plan 2012BAI05B01. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.