Proliferation at the heart of preadolescence

Nathan J Palpant; Charles E Murry

doi:10.1016/j.cell.2014.04.025

Proliferation at the heart of preadolescence

Cell. 2014 May 8;157(4):765-7. doi: 10.1016/j.cell.2014.04.025.

Authors

Nathan J Palpant¹, Charles E Murry²

Affiliations

¹ Departments of Pathology, Institute for Stem Cell and Regenerative Medicine, Center for Cardiovascular Biology, University of Washington, Seattle, WA 98109, USA.
² Departments of Pathology, Institute for Stem Cell and Regenerative Medicine, Center for Cardiovascular Biology, University of Washington, Seattle, WA 98109, USA; Bioengineering, Institute for Stem Cell and Regenerative Medicine, Center for Cardiovascular Biology, University of Washington, Seattle, WA 98109, USA; Medicine/Cardiology, Institute for Stem Cell and Regenerative Medicine, Center for Cardiovascular Biology, University of Washington, Seattle, WA 98109, USA. Electronic address: [email protected].

PMID: 24813600
DOI: 10.1016/j.cell.2014.04.025

Abstract

Cardiomyocytes, the cells of the heart muscle, lose nearly all of their proliferative capacity after birth, limiting the heart's ability to regenerate. Naqvi et al. now identify a transient burst of cardiomyocyte proliferation during preadolescence, driven by a thyroid hormone surge, with therapeutic implications for congenital and acquired heart diseases.

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MeSH terms

Animals
Cell Differentiation*
Cell Proliferation*
Heart / growth & development*
Male
Myocytes, Cardiac / cytology*