Principles of membrane tethering and fusion in endosome and lysosome biogenesis

Daniel Kümmel; Christian Ungermann

doi:10.1016/j.ceb.2014.04.007

Principles of membrane tethering and fusion in endosome and lysosome biogenesis

Curr Opin Cell Biol. 2014 Aug:29:61-6. doi: 10.1016/j.ceb.2014.04.007. Epub 2014 May 17.

Authors

Daniel Kümmel¹, Christian Ungermann²

Affiliations

¹ University of Osnabrück, Department of Biology/Chemistry, Biochemistry Section, Barbarastrasse 13, Osnabrück 49076, Germany. Electronic address: [email protected].
² University of Osnabrück, Department of Biology/Chemistry, Biochemistry Section, Barbarastrasse 13, Osnabrück 49076, Germany. Electronic address: [email protected].

PMID: 24813801
DOI: 10.1016/j.ceb.2014.04.007

Abstract

Endosomes and lysosomes receive cargo via vesicular carriers that arrive along multiple trafficking routes. On both organelles, tethering proteins have been identified that interact specifically with Rab5 on endosomes and Rab7 on late endosomes/lysosomes and that facilitate the SNARE-driven membrane fusion. Even though the structure and stoichiometry of the involved proteins and protein complexes differ strongly, they may operate by similar principles. Within this review, we will provide insights into their common functions and discuss the open questions in the field.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Endosomes / metabolism*
Humans
Lysosomes / metabolism*
Membrane Fusion*
Protein Binding
Protein Transport